Thanks to Craig for this one:
I found an interesting video for a blog post about biotic games. At Stanford University they have found a way to be able to manipulate paramecium and other single celled organisms, and write a program that essentially builds a video game focused around manipulating their movements.
It has an organism on a plate with a camera looking down on it, and the controller has buttons on it that are connected to specific catalysts that influence
the movement of the paramecia. The UI for the game is basically placed over the camera screen and it is programmed to be affected by the movement of the
paramecia based on the objective of the game. I thought it was very interesting.
Here are the links:
http://www.youtube.com/watch?v=f2Ux4pQH7KY&feature=player_embedded (original video)
http://www.gameinformer.com/b/news/archive/2011/01/14/stanford-researchers-play-games-in-real-life_2c00_-with-real-life.aspx (article that I found the video on)